DNA DAMAGE INDUCED BY HYPOCRELLIN-A PHOTOSENSITIZATION

被引：15

作者：

CAO, EH

XIN, SM

CHENG, LS

机构：

[1] Institute of Biophysics, Academia Sinica, Beijing

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1992年 / 61卷 / 02期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1080/09553009214550841

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hypocrellin-A (HC-A) isolated from Hypocrellia bambusae Sacc., is a new and effective photosensitizer. Illumination of sarcoma 180 cells with visible light in the presence of HC-A leads to a decrease in cell viability and H-3-TdR incorporation, causes DNA strand breakage, and results in the selective destruction of guanine moieties in DNA. HC-A photosensitization causes an increase in the theta-260/theta-280 ratio in the circular dichroism spectra of DNA in vitro. Of the four usual 2'-deoxynucleotides illuminated in the presence of HC-A only 2'-deoxyguanylic acid was destroyed.

引用

页码：213 / 219

页数：7