EFFECTS OF ANTIGLAUCOMA DRUGS ON OCULAR BLOOD-FLOW IN OCULAR HYPERTENSIVE RABBITS

被引：36

作者：

CHIOU, GCY

CHEN, YJ

机构：

[1] Institute of Ocular Pharmacology, Department ofMedical Pharmacology and Toxicology, Texas A&M University College ofMedicine, Texas, College Station

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1993年 / 9卷 / 01期

关键词：

D O I：

10.1089/jop.1993.9.13

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Antiglaucoma drugs were studied systematically on the ocular blood flow in ocular hypertensive rabbits. As expected, pilocarpine, clonidine and acetazolamide were all found to increase the ocular blood flow in the retina and choroid. However, their use in the clinics was much less than the beta-blockers, such as L-timolol, levobunolol, betaxolol and metipranolol. It was surprising to find that all non-specific and beta1-specific adrenergic blockers decreased the ocular blood flow in ocular hypertensive rabbits. If this finding holds true in human patients, the use of beta-blockers for glaucoma treatment should be reconsidered. Dopamine antagonists, such as droperidol, metoclopramide and loxapine, were found to increase the ocular blood flow. Therefore, they might be able to replace beta-blockers for glaucoma treatment.

引用

页码：13 / 24

页数：12

共 20 条

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