ANTI-PRES2 NEUTRALIZES THE HEPATITIS-B VIRUS VARIANT WITH A VACCINE-ESCAPE MUTATION AT THE AMINO-ACID POSITION-126 OR POSITION-145 WITHIN THE S-GENE

被引：3

作者：

MACHIDA, A

OKAMOTO, H

TSUDA, F

TANAKA, T

DOMOTO, K

MISHIRO, S

机构：

[1] INST IMMUNOL,KORAKO 1-1-10,BUNKYO KU,TOKYO 112,JAPAN

[2] YAMANASHI INST PUBL HLTH,KOFU,YAMANASHI 400,JAPAN

[3] JICHI MED SCH,DIV IMMUNOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

[4] VIRAL HEPATTIS RES FDN JAPAN,BUNKYO KU,TOKYO 113,JAPAN

[5] JAPANESE RED CROSS,SAITAMA BLOOD CTR,YONO,SAITAMA 338,JAPAN

[6] TAKEDA CHEM IND CO LTD,DIV PHARMACEUT DEV,CHUO KU,TOKYO 103,JAPAN

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1994年 / 2卷 / 03期

关键词：

PRES2; EPITOPE; VACCINE-ESCAPE HBV MUTANT; S126; MUTANT; S145; PRES2-CONTAINING VACCINE;

D O I：

10.1016/0928-4346(94)90056-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We analyzed the surface epitopes of hepatitis B virus (HBV) virions with two types of vaccine-escape mutations within the S gene (S126 and S145) by in vitro neutralization study using affinity chromatography. Each of the two epitopes of the S gene product (recognized by monoclonal antibodies Nos. 3207 and 7604) was lost significantly from the surface of HBV virions with the S145 or S126 mutation. However, the preS2 epitope recognized by the No. 5520 monoclonal was preserved on the virion surface of both mutants. Our results, thus, suggest that a preS2-containing vaccine could possibly prevent infections with HBV S gene mutants that escape from or evolve after immunization with conventional vaccine and hepatitis B immune globulin (HBIG).

引用

页码：186 / 189

页数：4

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