STRUCTURE AND FUNCTIONS OF ARRESTINS

被引：72

作者：

PALCZEWSKI, K ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT PHARMACOL, SEATTLE, WA 98195 USA

来源：

PROTEIN SCIENCE | 1994年 / 3卷 / 09期

关键词：

ARRESTINS; PROTEIN KINASES; RECEPTOR INACTIVATION; TRANSMEMBRANE SIGNAL TRANSDUCTION;

D O I：

10.1002/pro.5560030901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transmembrane signal transductions in a variety of cell types that mediate signals as diverse as those carried by neurotransmitters, hormones, and sensory signals share basic biochemical mechanisms that include: (1) an extracellular perturbation (neurotransmitter, hormone, odor, light); (2) specific receptors; (3) coupling proteins, such as G proteins; and (4) effector enzymes or ion channels. Parallel to these amplification reactions, receptors are precisely inactivated by mechanisms that involve protein kinases and regulatory proteins called arrestins. The structure and functions of arrestins are the focus of this review.

引用

页码：1355 / 1361

页数：7

共 71 条

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