EFFECT OF SIMVASTATIN ON DESATURASE ACTIVITIES IN LIVER FROM LEAN AND OBESE ZUCKER RATS

被引：9

作者：

GEORGES, B ^{[1
]}

BLOND, JP ^{[1
]}

MANIONGUI, C ^{[1
]}

BEZARD, J ^{[1
]}

机构：

[1] UNIV BOURGOGNE,FAC SCI MIRANDE,UNITE RECH NUTR CELLULAIRE & METAB,BP 138,F-21004 DIJON,FRANCE

来源：

LIPIDS | 1993年 / 28卷 / 01期

关键词：

D O I：

10.1007/BF02536363

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of simvastatin, a hypocholesterolemic drug, on the biosynthesis of arachidonic acid was studied in obese and lean Zucker rats. After administration of 2 mg/kg body weight/d f or 13 d, DELTA6 and DELTA5 desaturase activities were measured in liver microsomes at two substrate concentrations. In untreated rats, the DELTA6 desaturation rate was similar in the obese and lean rats when measured at saturating substrate levels, whereas DELTA5 desaturation was lower in the obese animals. Treatment with simvastatin did not change DELTA6 desaturation in either phenotype but increased DELTA5 desaturation in obese rats to reach the unchanged rate observed in lean animals. The changes were not reflected in the fatty acid composition of liver microsomal phospholipids when expressed as mug fatty acid/g of liver.

引用

页码：63 / 65

页数：3

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