DETERMINATION OF CELIPROLOL BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND STABILITY IN SOLUTION

被引：6

作者：

MODAMIO, P ^{[1
]}

LASTRA, CF ^{[1
]}

MARINO, EL ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC PHARM,DEPT PHARM,PHARMACOTHERAPY UNIT,E-08028 BARCELONA,SPAIN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 107卷 / 03期

关键词：

CELIPROLOL HYDROCHLORIDE; HPLC; STABILITY; NONLINEAR REGRESSION; KINETIC ORDER; SHELF-LIFE;

D O I：

10.1016/0378-5173(94)90441-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An isocratic technique was developed for the analysis of Celiprolol HCl using high-performance liquid chromatography (HPLC) with UV detection and a C-18 reverse-phase column. The coefficient of variation (C.V.) for precision and proportionality assays was lower than 5% for all concentrations studied. The stability of the drug in solution was studied. We deduced that the shelf-life (t(90%)) of Celiprolol HCl at room temperature (25 degrees C) was 13.8 days.

引用

页码：243 / 245

页数：3

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