EFFECT OF AGE AND POSTSPLENECTOMY INTERVAL ON THE SUSCEPTIBILITY OF THE ASPLENIC ADULT RAT TO PNEUMOCOCCAL CHALLENGE

被引：9

作者：

GOLDTHORN, JF

SCHWARTZ, AD

机构：

[1] UNIV MARYLAND, SCH MED, DEPT PEDIAT, BALTIMORE, MD 21201 USA

[2] UNIV MARYLAND, SCH MED, DEPT SURG, BALTIMORE, MD 21201 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 1979年 / 11卷 / 01期

关键词：

asplenia; pneumococcus; spleen;

D O I：

10.1002/jso.2930110110

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The response to i.v. challenge with pneumococcus was examined in asplenic and sham-operated adult Sprague-Dawley rats 18 wk following surgery. The LD50 was over 2000-fold greater in the sham-operated animals than in the asplenic animals. The age of an asplenic host, the length of time following splenectomy and the presence of a normal immune system other than the asplenic state may not in themselves confer immunity.

引用

页码：53 / 57

页数：5

共 29 条

[1] POLYVALENT PNEUMOCOCCAL-POLYSACCHARIDE IMMUNIZATION OF PATIENTS WITH SICKLE-CELL-ANEMIA AND PATIENTS WITH SPLENECTOMY
AMMANN, AJ
ADDIEGO, J
WARA, DW
LUBIN, B
SMITH, WB
MENTZER, WC
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1977, 297 (17) : 897 - 900
[2] OVERWHELMING SEPSIS FOLLOWING SPLENECTOMY FOR TRAUMA
BALFANZ, JR
NESBIT, ME
JARVIS, C
KRIVIT, W
[J]. JOURNAL OF PEDIATRICS, 1976, 88 (03) : 458 - 460
[3] BURRINGTON JD, 1977, ARCH SURG-CHICAGO, V112, P417
[4] IMMUNOLOGICAL STUDIES IN POST-SPLENECTOMY SYNDROME
CLARET, I
MORALES, L
MONTANER, A
[J]. JOURNAL OF PEDIATRIC SURGERY, 1975, 10 (01) : 59 - 64
[5] DEFECTIVE PHAGOCYTOSIS DUE TO TUFTSIN DEFICIENCY IN SPLENECTOMIZED SUBJECTS
CONSTANT.A
NAJJAR, VA
WISH, JB
NECHELES, TH
STOLBACH, LL
[J]. AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1973, 125 (05): : 663 - 665
[6] CONSERVATIVE MANAGEMENT OF SPLENIC TRAUMA
DOUGLAS, GJ
SIMPSON, JS
[J]. JOURNAL OF PEDIATRIC SURGERY, 1971, 6 (05) : 565 - &
[7] ELLIS EF, 1966, PEDIATRICS, V37, P111
[8] HAZARD OF OVERWHELMING INFECTION AFTER SPLENECTOMY IN CHILDHOOD
ERAKLIS, AJ
KEVY, SV
DIAMOND, LK
GROSS, RE
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1967, 276 (22) : 1225 - &
[9] ERICKSON WD, 1968, AM J DIS CHILD, V116, P1
[10] CHANGING PATTERN OF NEONATAL SUSCEPTIBILITY TO HEMOPHILUS INFLUENZAE
GRABER, CD
GERSHANIK, JJ
LEVKOFF, AH
[J]. JOURNAL OF PEDIATRICS, 1971, 78 (06) : 948 - +

← 1 2 3 →