THE NEUROBIOLOGY OF NARCOLEPSY

被引：24

作者：

ALDRICH, MS

机构：

[1] Sleep Disorders Center, Taubman Center 1920, University of Michigan Medical Center, Ann Arbor, MI 48109-0316

来源：

TRENDS IN NEUROSCIENCES | 1991年 / 14卷 / 06期

关键词：

D O I：

10.1016/0166-2236(91)90121-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Narcolepsy is characterized by excessive sleepiness and abnormal manifestations of rapid eye movement (REM) sleep. Neurochemical studies of human and canine narcolepsy have demonstrated disturbed monoaminergic and cholinergic function and suggest that deficits of noradrenaline availability in specific brain regions may account for much of its disordered pathophysiology. Genetic susceptibility to narcolepsy is closely linked to a specific region of the major histocompatibility complex on chromosome 6 and an important direction for future research will be to unravel the relationship between this gene region and the neurochemical abnormalities of narcolepsy.

引用

页码：235 / 239

页数：5

共 42 条

[1]

ALDRICH MS, 1990, NEW ENGL J MED, V323, P389

[2] EXACERBATION OF HUMAN CATAPLEXY BY PRAZOSIN [J].

ALDRICH, MS ;

ROGERS, AE .

SLEEP, 1989, 12 (03) :254-256

[3]

ALDRICH MS, 1990, SLEEP RES, V19, P180

[4]

ANDREASZIETZ A, 1986, LANCET, V2, P684

[5] THE CARBACHOL-INDUCED ENHANCEMENT OF DESYNCHRONIZED SLEEP SIGNS IS DOSE DEPENDENT AND ANTAGONIZED BY CENTRALLY ADMINISTERED ATROPINE [J].

BAGHDOYAN, HA ;

LYDIC, R ;

CALLAWAY, CW ;

HOBSON, JA .

NEUROPSYCHOPHARMACOLOGY, 1989, 2 (01) :67-79

[6]

Berman A.L., 1968, BRAIN STEM CAT CYTOA

[7] BRAIN DOPAMINE RECEPTOR LEVELS ELEVATED IN CANINE NARCOLEPSY [J].

BOWERSOX, SS ;

KILDUFF, TS ;

FAULL, KF ;

ZELLERDEAMICIS, L ;

DEMENT, WC ;

CIARANELLO, RD .

BRAIN RESEARCH, 1987, 402 (01) :44-48

[8]

BOWERSOX SS, 1987, SLEEP RES, V16, P312

[9]

BOWERSOX SS, 1987, SLEEP RES, V16, P313

[10] EXCESSIVE DAYTIME SLEEPINESS AND THE PATHOPHYSIOLOGY OF NARCOLEPSY-CATAPLEXY - A LABORATORY PERSPECTIVE [J].

BROUGHTON, R ;

VALLEY, V ;

AGUIRRE, M ;

ROBERTS, J ;

SUWALSKI, W ;

DUNHAM, W .

SLEEP, 1986, 9 (01) :205-215

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