SPINAL-CORD REGENERATION IN RATS MADE IMMUNOLOGICALLY UNRESPONSIVE TO CNS ANTIGENS

被引：11

作者：

FERINGA, ER

NELSON, KR

VAHLSING, HL

DAUSER, RC

机构：

[1] UNIV MICHIGAN,MED CTR,ANN ARBOR,MI 48109

[2] VET ADM HOSP,MED CTR,DEPT PATHOL,ANN ARBOR,MI 48105

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1979年 / 42卷 / 07期

关键词：

D O I：

10.1136/jnnp.42.7.642

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seventy days after complete spinal cord transection, both treated and untreated rats showed evidence that some corticospinal axons had regenerated. Rats made immunologically unresponsive to CNS tissue showed no increase in corticospinal regeneration as measured by orthograde axoplasmic flow of tritiated proline or retrograde axoplasmic labelling with horseradish peroxidase. However, treated rats did demonstrate electrophysiological evidence of regeneration of long ascending sensory pathways. Tolerant animals additionally treated with cyclophosphamide showed corticospinal axonal regeneration by tritiated proline transport and electrophysiological techniques and also showed electrophysiological evidence of ascending sensory tract regeneration.

引用

页码：642 / 648

页数：7

共 24 条

[1] EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - DEMYELINATING ACTIVITY OF SERUM AND SENSITIZED LYMPH NODE CELLS ON CULTURED NERVE TISSUES [J].