THE EFFECT OF VALPROIC ACID ON 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOLEACETIC ACID CONCENTRATION IN HIPPOCAMPAL DIALYSATES INVIVO

被引:59
作者
WHITTON, PS
FOWLER, LJ
机构
[1] Department of Pharmacology, The School of Pharmacy, London, WC1N 1AX
关键词
VALPROATE; 5-HT; (5-HYDDROXYTRYPTAMINE; SEROTONIN); MICRODIALYSIS;
D O I
10.1016/0014-2999(91)90681-F
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of valproic acid (100, 200 and 400 mg/kg i.p.) on extracellular 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) has been studied using intracerebral microdialysis of the ventral hippocampus. Valproate caused a dose-dependent increase in dialysate 5-HT, but in contrast no effect on 5-HIAA level was observed. These findings are considered with regard to a possible role of 5-HT in mediating the anticonvulsant action of valproate.
引用
收藏
页码:167 / 169
页数:3
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