COMPARISON OF THE EFFECT OF TEMAFLOXACIN, CIPROFLOXACIN, OR PLACEBO ON CEREBRAL BLOOD-FLOW, GLUCOSE, AND OXYGEN-METABOLISM IN HEALTHY-SUBJECTS BY MEANS OF POSITRON EMISSION TOMOGRAPHY

被引：11

作者：

BEDNARCZYK, EM

GREEN, JA

NELSON, AD

LEISURE, GA

LITTLE, D

ADLER, LP

BERRIDGE, MS

PANACEK, EA

MIRALDI, FD

机构：

[1] CASE WESTERN RESERVE UNIV, SCH MED, DEPT MED, CLEVELAND, OH 44106 USA

[2] CASE WESTERN RESERVE UNIV, SCH MED, DEPT PHARMACOL, CLEVELAND, OH 44106 USA

[3] CASE WESTERN RESERVE UNIV, SCH MED, DEPT FAMILY MED, CLEVELAND, OH 44106 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1991年 / 50卷 / 02期

关键词：

D O I：

10.1038/clpt.1991.121

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Study objective: To determine the cause of the central nervous system effect of the fluorinated quinolones temafloxacin and ciprofloxacin by measuring cerebral blood flow and metabolism by use of positron emission tomography. Design: This was a prospective, randomized, double-blind, placebo-controlled study. Patients: The patients were 13 healthy, nonsmoking volunteers whose ages ranged from 18 to 40 years. Results: We measured brain blood flow and metabolism by use of positron emission tomography before and after a five-dose course of 750 mg ciprofloxacin, 600 mg temafloxacin, or placebo given every 12 hours.

引用

页码：165 / 171

页数：7

共 46 条

[1]

ADLER L, 1990, RADIOLOGY, V173, P37

[2]

ADLER LP, 1989, RADIOLOGY, V173, pP78

[3]

ARCIERI G, 1987, AM J MED, V82, P381

[4] CIPROFLOXACIN - AN OVERVIEW OF ADVERSE EXPERIENCES [J].