IMIDAZOLE RECEPTORS AND CLONIDINE-DISPLACING SUBSTANCE IN RELATIONSHIP TO CONTROL OF BLOOD-PRESSURE, NEUROPROTECTION, AND ADRENOMEDULLARY SECRETION

被引：36

作者：

REIS, DJ

REGUNATHAN, S

MEELEY, MP

机构：

[1] Division of Neurobiology, Cornell University Medical College, New York, NY, 10021

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1992年 / 5卷 / 04期

关键词：

IMIDAZOLE RECEPTORS; VENTROLATERAL MEDULLA; FOCAL CEREBRAL ISCHEMIA; ADRENAL MEDULLA; CATECHOLAMINES;

D O I：

10.1093/ajh/5.4.51S

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Clonidine, idazoxan, rilmenidine, and comparable agents bind to imidazol(in)e (IR), as well as alpha-2-adrenergic, receptors. Interaction with IRs mediates the hypotension elicited by these drugs at their site of action in the rostral ventrolateral medulla oblongata (RVL) and probably the neuroprotection in focal ischemic cerebral infarction. Unlike alpha-2-adrenergic receptors, IRs are not coupled to G-proteins. Their native ligand may be clonidine-displacing substance (CDS), a potent, partially purified adrenomedullary secretagogue, distributed regionally in brain and some peripheral organs. IRs and CDS may be important in the genesis, expression, and/or therapy of hypertension and stroke.

引用

页码：S51 / S57

页数：7

共 15 条

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