THE PINEAL HORMONE MELATONIN INHIBITS DNA-ADDUCT FORMATION INDUCED BY THE CHEMICAL CARCINOGEN SAFROLE IN-VIVO

被引：269

作者：

TAN, DX ^{[1
]}

POEGGELER, B ^{[1
]}

REITER, RJ ^{[1
]}

CHEN, LD ^{[1
]}

CHEN, S ^{[1
]}

MANCHESTER, LC ^{[1
]}

BARLOWWALDEN, LR ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284

来源：

CANCER LETTERS | 1993年 / 70卷 / 1-2期

关键词：

SAFROLE; CARCINOGEN; MELATONIN; DNA ADDUCT;

D O I：

10.1016/0304-3835(93)90076-L

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by P-32-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 +/- 2290 counts/min/10 mug DNA. Coadministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 +/- 987 counts/min/10 mug DNA and 462 +/- 283 counts/min/10 mug DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 +/- 8, 3140 +/- 430 and 10 040 +/- 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

引用

页码：65 / 71

页数：7

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