PEPTIDE-BASED P21(RAS) FARNESYL TRANSFERASE INHIBITORS - SYSTEMATIC MODIFICATION OF THE TETRAPEPTIDE CA(1)A(2)X MOTIF

被引：38

作者：

LEFTHERIS, K

KLINE, T

NATARAJAN, S

DEVIRGILIO, MK

CHO, YH

PLUSCEC, J

RICCA, C

ROBINSON, S

SEIZINGER, BR

MANNE, V

MEYERS, CA

机构：

[1] The Bristol-Meyers Squibb Pharmaceutical Research Institute, Princeton, NJ 08540

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80257-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A systematic study of CVFM, a CAAX-derived farnesyl transferase inhibitor, was undertaken to determine the structural elements important for intrinsic activity as well as substrate character. Results indicate a narrowly defined profile for nonsubstrate FT inhibition.

引用

页码：887 / 892

页数：6

共 25 条

[1] Bodanszky M., 1984, PRINCIPLES PEPTIDE S, DOI [10.1007/978-3-642-96835-8, DOI 10.1007/978-3-642-96835-8]
[2] CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT
BORCH, RF
BERNSTEIN, MD
DURST, HD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (12) : 2897 - +
[3] TETRAPEPTIDE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE - AMINO-TERMINAL SUBSTITUTION IN PHENYLALANINE-CONTAINING TETRAPEPTIDES RESTORES FARNESYLATION
BROWN, MS
GOLDSTEIN, JL
PARIS, KJ
BURNIER, JP
MARSTERS, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (17) : 8313 - 8316
[4] P21RAS IS MODIFIED BY A FARNESYL ISOPRENOID
CASEY, PJ
SOLSKI, PA
DER, CJ
BUSS, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (21) : 8323 - 8327
[5] N-METHYLAMINO ACIDS IN PEPTIDE-SYNTHESIS .5. SYNTHESIS OF N-TERT-BUTYLOXYCARBONYL, N-METHYLAMINO ACIDS BY N-METHYLATION
CHEUNG, ST
BENOITON, NL
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (05): : 906 - 910
[6] STUDIES ON AMINO-ACIDS AND PEPTIDES .6. METHODS FOR INTRODUCING THIOAMIDE BONDS INTO THE PEPTIDE BACKBONE - SYNTHESIS OF THE 4 MONOTHIO ANALOGS OF LEUCINE ENKEPHALIN
CLAUSEN, K
THORSEN, M
LAWESSON, SO
SPATOLA, AF
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (04): : 785 - 798
[7] DIAGOMESEGUER J, 1980, SYNTHESIS-STUTTGART, P547
[8] FEHRENTZ JA, 1985, INT J PEPT PROT RES, V26, P236
[9] SOLID-PHASE PEPTIDE-SYNTHESIS UTILIZING 9-FLUORENYLMETHOXYCARBONYL AMINO-ACIDS
FIELDS, GB
NOBLE, RL
[J]. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1990, 35 (03): : 161 - 214
[10] FRIEDINGER RM, 1983, J ORG CHEM, V48, P77

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