ADP RIBOSYL CYCLASE ACTIVITY OF A NOVEL BONE-MARROW STROMAL CELL-SURFACE MOLECULE, BST-1

被引：160

作者：

HIRATA, Y

KIMURA, N

SATO, K

OHSUGI, Y

TAKASAWA, S

OKAMOTO, H

ISHIKAWA, J

KAISHO, T

ISHIHARA, K

HIRANO, T

机构：

[1] CHUGAI PHARMACEUT CO LTD,FUJI GOTEMBA RES LABS,GOTEMBA,SHIZUOKA,JAPAN

[2] TOHOKU UNIV,SCH MED,DEPT BIOCHEM,SENDAI,MIYAGI 98077,JAPAN

[3] OSAKA UNIV,SCH MED,BIOMED RES CTR,DEPT ONCOL,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1994年 / 356卷 / 2-3期

关键词：

BST-1; CD38; ADP RIBOSYL CYCLASE; CADPR HYDROLASE;

D O I：

10.1016/0014-5793(94)01279-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human BST-1, a bone marrow stromal cell surface molecule, is a GPI-anchored protein that facilitates the growth of pre-B cells. The deduced amino acid sequences of human and mouse BST-1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl cyclase. Therefore, like CD38, BST-1 might possess ADP ribosyl cyclase activity. Here, we report the establishment of a stable transformant CHO cell line, which secretes truncated human soluble BST-1, and show that purified soluble BST-1 displays both ADP ribosyl cyclase and cADPR hydrolase activities.

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收藏

页码：244 / 248

页数：5

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