A brute force dichotomization approach to quantitative trait linkage analysis

被引：7

作者：

Bailey, JN ^{[1
]}

Almasy, L ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT GENET,NEW HAVEN,CT 06510

来源：

GENETIC EPIDEMIOLOGY | 1995年 / 12卷 / 06期

关键词：

linkage analysis; quantitative trait; simulation;

D O I：

10.1002/gepi.1370120631

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichotomization does not in itself preclude the detection of loci which account for as little as 16% of the genetic variance of the disease. The effects of inclusion of known covariates and quantitative trait linkage analysis are also discussed. (C) 1995 Wiley-Liss, Inc.

引用

页码：719 / 722

页数：4