EPSTEIN-BARR-VIRUS INDUCTION OF RECOMBINASE-ACTIVATING GENES RAG1 AND RAG2

被引：70

作者：

SRINIVAS, SK

SIXBEY, JW

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT INFECT DIS, MEMPHIS, TN 38101 USA

[2] ST JUDE CHILDRENS RES HOSP, DEPT VIROL & MOLEC BIOL, MEMPHIS, TN 38101 USA

[3] UNIV TENNESSEE, COLL MED, MEMPHIS, TN USA

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 12期

关键词：

D O I：

10.1128/JVI.69.12.8155-8158.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In experimental B-cell infections, Epstein-Barr virus induced sustained expression of V(D)J recombinase-activating genes RAG1 and RAG2, whose aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms. In cell lines in which RAG1 and RAG2 were detected, virus integrated into cellular DNA rather than assumed the configuration of extrachromosomal episomes. Expression of the Epstein-Barr virus nuclear antigen 1 in transient transfection assays was sufficient to induce both recombinase-activating genes.

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页码：8155 / 8158

页数：4

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