ANALYSIS OF THE ROLE OF CYSTEINE RESIDUES IN ISOPENICILLIN-N SYNTHETASE-ACTIVITY BY SITE-DIRECTED MUTAGENESIS

被引:47
作者
SAMSON, SM [1 ]
CHAPMAN, JL [1 ]
BELAGAJE, R [1 ]
QUEENER, SW [1 ]
INGOLIA, TD [1 ]
机构
[1] ELI LILLY & CO,LILLY CORP CTR,INDIANAPOLIS,IN 46285
关键词
D O I
10.1073/pnas.84.16.5705
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:5705 / 5709
页数:5
相关论文
共 15 条
[1]  
Abraham EP, 1981, RECENT ADV CHEM BETA, P125
[2]   INVITRO DELETIONAL MUTAGENESIS FOR BACTERIAL PRODUCTION OF THE 20,000-DALTON FORM OF HUMAN PITUITARY GROWTH-HORMONE [J].
ADELMAN, JP ;
HAYFLICK, JS ;
VASSER, M ;
SEEBURG, PH .
DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1983, 2 (03) :183-193
[3]   IRON-SULFUR STOICHIOMETRY AND STRUCTURE OF IRON-SULFUR CLUSTERS IN 3-IRON PROTEINS - EVIDENCE FOR [3FE-4S] CLUSTERS [J].
BEINERT, H ;
EMPTAGE, MH ;
DREYER, JL ;
SCOTT, RA ;
HAHN, JE ;
HODGSON, KO ;
THOMSON, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (02) :393-396
[4]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[5]   CLONING AND EXPRESSION OF THE ISOPENICILLIN-N SYNTHETASE GENE FROM PENICILLIUM-CHRYSOGENUM [J].
CARR, LG ;
SKATRUD, PL ;
SCHEETZ, ME ;
QUEENER, SW ;
INGOLIA, TD .
GENE, 1986, 48 (2-3) :257-266
[6]   IRON-SULFUR CLUSTERS AND PROTEIN-STRUCTURE OF AZOTOBACTER FERREDOXIN AT 2.0 A RESOLUTION [J].
GHOSH, D ;
ODONNELL, S ;
FUREY, W ;
ROBBINS, AH ;
STOUT, CD .
JOURNAL OF MOLECULAR BIOLOGY, 1982, 158 (01) :73-109
[7]   TRANSFERRIN - A STUDY OF THE IRON-BINDING SITES USING EXTENDED X-RAY ABSORPTION FINE-STRUCTURE AND ANOMALOUS DISPERSION TECHNIQUES [J].
LINDLEY, PF ;
BAILEY, S ;
EVANS, RW ;
GARRATT, RC ;
GORINSKY, B ;
HASNAIN, SS ;
SARRA, R .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1986, 14 (03) :542-545
[8]  
MANIATIS T, 1982, MOL CLONING LABORATO
[9]   NEW METHOD FOR SEQUENCING DNA [J].
MAXAM, AM ;
GILBERT, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (02) :560-564
[10]  
OKAMURAIKEDA K, 1985, J BIOL CHEM, V260, P1338