EVIDENCE FOR PROTECTIVE EFFECT OF AN INACTIVATED RHINOVIRUS VACCINE ADMINISTERED BY NASAL ROUTE

被引:91
作者
PERKINS, JC
TUCKER, DN
KNOPF, HLS
WENZEL, RP
HORNICK, RB
KAPIKIAN, AZ
CHANOCK, RM
机构
[1] Laboratory of Infectious Diseases, NIAID, NIH, Bethesda
[2] Division of Infectious Diseases, University of Maryland, Baltimore
关键词
Antibodies; Globulins; Immunization; Rhinovirus; Vaccines;
D O I
10.1093/oxfordjournals.aje.a121076
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Perkins, J. C (Lab. Infectious Diseases, NIAID, NIH, Bethesda, Md. 20014), D. N. Tucker, H. L S. Knopf, R. P. Wenzel, R. B. Homick, A. Z. Kapikian and R. M. Qianock. Evidence for protective effect of an inactivated rhinovirus vacdne administered by the nasal route. Amer. L Epid., 1969, 90: 319-326.-The antigenidty and protective effect of an inactivated rhinovirus type 13 vacdne administered intranasally (IN) were evaluated in adult male volunteers. After IN vacdnation, 14 of 17 vaccinees developed a fourfold or greater rise in nasal and/or serum antibody. A significant protective effect of the IN vacdne was seen when the men were challenged with 101.7-102.5 TCD50 of type 13 virus-11 of 13 seronegative controls became ill while only 4 of 12 vaccinees developed illness (p < 0.05). © 1969, by THE JOHNS HOPKINS UNIVERSITY.
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页码:319 / &
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