The Effects of TGF beta on Haemopoietic Cells

被引：37

作者：

Hampson, J. ^{[1
]}

Ponting, I. L. O. ^{[1
]}

Cook, N. ^{[2
]}

Vodinelich, L. ^{[3
]}

Redmond, S. ^{[3
]}

Roberts, A. B. ^{[4
]}

Dexter, T. M. ^{[1
]}

机构：

[1] Christie Hosp & Holt Radium Inst, Paterson Inst Canc Res, Dept Expt Haematol, Wilmslow Rd, Manchester M20 9BX, Lancs, England

[2] UMIST, Dept Biochem & Appl Mol Biol, Sackville St, Manchester, Lancs, England

[3] Celltech Ltd, Bath Rd, Slough, Berks, England

[4] NCI, Lab Chemoprevent, Bethesda, MD 20892 USA

来源：

GROWTH FACTORS | 1989年 / 1卷 / 02期

关键词：

TGF beta haemopoiesis; stem cells;

D O I：

10.3109/08977198909029128

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor beta (TGF beta) suppresses the growth of differentiation inducible, murine IL-3-dependent multipotential cell lines but has no growth inhibitory effect upon an IL-3-independent (leukaemic) cell line arising from one of them, nor on IL-3-dependent cell lines that are unable to undergo differentiation. TGF beta inhibits in vitro colony formation by normal multipotential haemopoietic progenitor cells. Bipotential progenitors recruited by CM-CSF are, however, more resistant to the inhibitory effects of TGF beta, whereas progenitors recruited by the lineage restricted factor, M-CSF, are sensitive to the inhibitory effects. These data indicate that responsiveness to TCF beta is differentiation linked and studies with the cell lines suggest that response ( or lack of response) is not determined solely by levels of expression of TGF beta receptors. Furthermore, the effects of TGF beta 2 on haemopoietic progenitors are very similar to those induced by TGFP.

引用

页码：193 / 202

页数：10

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