SOMATOSTATIN INHIBITS NEURALLY STIMULATED PANCREATIC-SECRETION INDIRECTLY

被引：13

作者：

HOLST, JJ

DEMUCKADELL, OBS

FAHRENKRUG, J

机构：

[1] Institute of Medical Physiology C, University of Copenhagen

[2] Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen

来源：

PANCREAS | 1990年 / 5卷 / 05期

关键词：

Acetylcholine; Bicarbonate secretion; Pancreatic enzyme secretion; Pancreatic juice; Parasympathetic nerves; Vagus nerves;

D O I：

10.1097/00006676-199009000-00018

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We studied the effect of a primed i.v. infusion of somatostatin (100 μg as a bolus, 0.5 p, g x kg-lx min-1) on pancreatic exocrine secretion in response to electrical stimulation of the vagus nerves and intra-arterial infusions of acetylcholine (0.5 mg x min-1) in anesthetized pigs (17-22 kg). In control experiments, vagus stimulation and acetylcholine increased protein secretion 31-to 80-fold and 106-fold, respectively. Somatostatin inhibited the response to vagus stimulation by more than 90%, whereas the response to acetylcholine remained unaffected. It is concluded that the inhibitory action of somatostatin on the vagally induced secretion must be due to an inhibition of the impulse transmission in the efferent parasympathetic nerves to the pancreas, and it is suggested that this mechanism contributes to the inhibitory effect of somatostatin observed with other stimuli as well. © 1990 Raven Press, Ltd., New York.

引用

页码：611 / 614

页数：4

共 20 条

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