EVIDENCE FOR A PSEUDOAUTOSOMAL LOCUS FOR SCHIZOPHRENIA .2. REPLICATION OF A NONRANDOM SEGREGATION OF ALLELES AT THE DXYS14 LOCUS

被引：39

作者：

DAMATO, T

CAMPION, D

GORWOOD, P

JAY, M

SABATE, O

PETIT, C

ABBAR, M

MALAFOSSE, A

LEBOYER, M

HILLAIRE, D

CLERGETDARPOUX, F

FEINGOLD, J

WAKSMAN, G

MALLET, J

机构：

[1] LAB NEUROBIOL CELLULAIRE & MOLEC,CNRS,UPR0023,1 AVE TERRASSE,F-91198 GIF SUR YVETTE,FRANCE

[2] CTR HOSP SPECIALISE ROUVRAY,F-6977 LYON,FRANCE

[3] CTR HOSP SPECIALISE ROUVRAY,DEPT RECH,F-76300 SOTTEVILLE ROUENS,FRANCE

[4] INSERM,U155,GENET EPIDEMIOL LAB,F-75016 PARIS,FRANCE

[5] CTR HOSP SPECIALISE ST PAUL,F-97460 ST PAUL,FRANCE

[6] INST PASTEUR,CNRS,UA 271,INSERM,U163,UNITE RECOMBINAISON & EXPRESS GENET,F-75724 PARIS 15,FRANCE

[7] CHU PITIE SALPETRIERE,F-75651 PARIS,FRANCE

[8] HOP FELIX GUYON,INSERM,F-97405 ST DENIS,FRANCE

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1992年 / 161卷

关键词：

D O I：

10.1192/bjp.161.1.59

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Because of an association between sexual aneuploidies and schizophrenia, and because schizophrenic siblings have been found to be more often of the same than of the opposite sex, the susceptibility locus for schizophrenia is thought to lie within the pseudoautosomal region of the sex chromosomes. We analysed 33 sibships comprising 18 pairs, 13 tribe, and 2 quartets of affected siblings, and found support for non-random segregation of alleles at the DXYS 1 4 locus in affected siblings. These findings are consistent with the pseudoautosomal hypothesis for schizophrenia and favour a genetic linkage between DXYS 14 and the disease.

引用

页码：59 / 62

页数：4

共 34 条

[1] *AM PSYCH ASS, 1980, DSM111
[2] *AM PSYCH ASS, 1987, DSM111R
[3] THE SCHEDULE FOR SCHIZOTYPAL PERSONALITIES (SSP) - A DIAGNOSTIC INTERVIEW FOR SCHIZOTYPAL FEATURES
BARON, M
ASNIS, L
GRUEN, R
[J]. PSYCHIATRY RESEARCH, 1981, 4 (02) : 213 - 228
[4] SEX-CHROMOSOMES - MAMMALIAN-X AND MAMMALIAN-Y CROSSOVER
BURGOYNE, PS
[J]. NATURE, 1986, 319 (6051) : 258 - 259
[5] POWER AND ROBUSTNESS OF THE LINKAGE HOMOGENEITY TEST IN GENETIC-ANALYSIS OF COMMON DISORDERS
CLERGETDARPOUX, F
BABRON, MC
BONAITIPELLIE, C
[J]. JOURNAL OF PSYCHIATRIC RESEARCH, 1987, 21 (04) : 625 - 630
[6] EVIDENCE FOR A PSEUDO-AUTOSOMAL LOCUS FOR SCHIZOPHRENIA USING THE METHOD OF AFFECTED SIBLING PAIRS
COLLINGE, J
DELISI, LE
BOCCIO, A
JOHNSTONE, EC
LANE, A
LARKIN, C
LEACH, M
LOFTHOUSE, R
OWEN, F
POULTER, M
SHAH, T
WALSH, C
CROW, TJ
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1991, 158 : 624 - 629
[7] HYPERVARIABLE TELOMERIC SEQUENCES FROM THE HUMAN SEX-CHROMOSOMES ARE PSEUDOAUTOSOMAL
COOKE, HJ
BROWN, WRA
RAPPOLD, GA
[J]. NATURE, 1985, 317 (6039) : 687 - 692
[8] A LOCUS CLOSER TO THE TELOMERE - REPLY
CROW, TJ
DELISI, LE
JOHNSTONE, EC
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1990, 156 : 416 - 420
[9] SEX-CHROMOSOMES AND PSYCHOSIS - THE CASE FOR A PSEUDOAUTOSOMAL LOCUS
CROW, TJ
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1988, 153 : 675 - 683
[10] CONCORDANCE BY SEX IN SIBLING PAIRS WITH SCHIZOPHRENIA IS PATERNALLY INHERITED - EVIDENCE FOR A PSEUDOAUTOSOMAL LOCUS
CROW, TJ
DELISI, LE
JOHNSTONE, EC
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1989, 155 : 92 - 97

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