RUTHENIUM RED DECREASES CAPSAICIN AND CITRIC ACID-INDUCED COUGH IN GUINEA-PIGS

被引：32

作者：

BOLSER, DC

AZIZ, SM

CHAPMAN, RW

机构：

[1] Schering-Plough Research, Bloomfield, NJ

来源：

NEUROSCIENCE LETTERS | 1991年 / 126卷 / 02期

关键词：

RUTHENIUM RED; COUGH; GUINEA PIG;

D O I：

10.1016/0304-3940(91)90536-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of aerosols of Ruthenium red (RR) on capsaicin- and citric acid-induced cough was investigated in guinea pigs. Aerosols of RR (0.3, 1, 3%) reduced capsaicin-induced cough in dose-dependent manner. Inhalation of RR also reduced cough produced by low, (200 mM) but not high (550 mM), concentrations of citric acid. These data suggest that RR is not a specific capsaicin antagonist and that citric acid and capsaicin share a common mechanism for activation of airway C-fibers that is RR sensitive. Furthermore, high concentrations of citric acid can elicit cough through a RR-insensitive mechanism.

引用

收藏

页码：131 / 133

页数：3

相关论文

共 19 条

[1] EFFECTS OF CODEINE, MORPHINE AND A NOVEL OPIOID PENTAPEPTIDE-BW443C, ON COUGH, NOCICEPTION AND VENTILATION IN THE UNANESTHETIZED GUINEA-PIG [J].

ADCOCK, JJ ;

SCHNEIDER, C ;

SMITH, TW .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (01) :93-100

[2] CAPSAICIN-INDUCED STIMULATION OF POLYMODAL NOCICEPTORS IS ANTAGONIZED BY RUTHENIUM RED INDEPENDENTLY OF EXTRACELLULAR CALCIUM [J].

AMANN, R ;

DONNERER, J ;

LEMBECK, F .

NEUROSCIENCE, 1989, 32 (01) :255-259

[3] RUTHENIUM RED SELECTIVELY PREVENTS CAPSAICIN-INDUCED NOCICEPTOR STIMULATION [J].

AMANN, R ;

LEMBECK, F .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 161 (2-3) :227-229

[4] THE EXPERIMENTAL PRODUCTION OF COUGH IN HUMAN SUBJECTS INDUCED BY CITRIC ACID AEROSOLS - PRELIMINARY STUDIES ON THE EVALUATION OF ANTITUSSIVE AGENTS [J].

BICKERMAN, HA ;

BARACH, AL .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1954, 228 (02) :156-163

[5]

BOVET D, 1972, NEUROMUSCULAR BLOCKI, V1, P243

[6] IMPULSE ACTIVITY IN AFFERENT VAGAL C-FIBERS WITH ENDINGS IN INTRAPULMONARY AIRWAYS OF DOGS [J].

COLERIDGE, HM ;

COLERIDGE, JCG .

RESPIRATION PHYSIOLOGY, 1977, 29 (02) :125-142

[7] CAPSAICIN INHALATION IN MAN AND THE EFFECTS OF SODIUM CROMOGLYCATE [J].

COLLIER, JG ;

FULLER, RW .

BRITISH JOURNAL OF PHARMACOLOGY, 1984, 81 (01) :113-117

[8] RUTHENIUM RED BLOCKS THE CAPSAICIN-INDUCED INCREASE IN INTRACELLULAR CALCIUM AND ACTIVATION OF MEMBRANE CURRENTS IN SENSORY NEURONS AS WELL AS THE ACTIVATION OF PERIPHERAL NOCICEPTORS INVITRO [J].

DRAY, A ;

FORBES, CA ;

BURGESS, GM .

NEUROSCIENCE LETTERS, 1990, 110 (1-2) :52-59

[9] COUGH INDUCED BY STIMULATION OF CAPSAICIN-SENSITIVE SENSORY NEURONS IN CONSCIOUS GUINEA-PIGS [J].

FORSBERG, K ;

KARLSSON, JA .

ACTA PHYSIOLOGICA SCANDINAVICA, 1986, 128 (02) :319-320

[10]

Forsberg K, 1988, Pulm Pharmacol, V1, P33, DOI 10.1016/0952-0600(88)90008-7