ACUTE MYELOGENOUS LEUKEMIA AND THROMBOCYTHEMIA ASSOCIATED WITH AN ABNORMALITY OF CHROMOSOME-3

The association of thrombocythemia with acute myelogenous leukemia (AML) is unusual. A patient with markedly increased platelet counts in association with abnormal megakaryocytes was diagnosed as having AML. In addition a karyotypic abnormality involving a translocation of the long arm of a No. 3 chromosome was identified by Q-banding techniques. The translocation involved the other chromosome No. 3 [ins (3;3) (q26;q21q26)]. A specific structural rearrangement in human chromosomes in AML may be associated with abnormal megakaryocytes and increased platelets. © 1979.