NEUROMUSCULAR-TRANSMISSION FAILURE DURING POSTNATAL-DEVELOPMENT

被引：42

作者：

FOURNIER, M

ALULA, M

SIECK, GC

机构：

[1] MAYO CLIN & MAYO FDN,DEPT ANESTHESIOL,ROCHESTER,MN 55905

[2] MAYO CLIN & MAYO FDN,DEPT PHYSIOL & BIOPHYS,ROCHESTER,MN 55905

[3] UNIV SO CALIF,DEPT BIOMED ENGN,LOS ANGELES,CA 90089

来源：

NEUROSCIENCE LETTERS | 1991年 / 125卷 / 01期

关键词：

DIAPHRAGM MUSCLE; FATIGUE; NEUROMUSCULAR JUNCTION; END-PLATE POTENTIAL; DEVELOPMENT; PHRENIC NERVE;

D O I：

10.1016/0304-3940(91)90124-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuromuscular transmission failure in rat diaphragm muscle was examined during the first two weeks of postnatal development, and was found to contribute significantly more to diaphragm fatigue induced by repetitive activation than in adult muscle. Intracellular analysis of evoked end-plate potentials indicated that neuromuscular transmission failure was due to both a block of action potential propagation and reduced synaptic efficacy.

引用

页码：34 / 36

页数：3

共 12 条

[1] FATIGUE OF ISOLATED RAT DIAPHRAGM - ROLE OF IMPAIRED NEUROMUSCULAR-TRANSMISSION [J].