SUBSTITUTED MONOCARBON CARBORANES INVOLVING THIOL, DISULFIDE OR DIMETHYL SULFIDE LIGANDS

被引：18

作者：

KHAN, SA

MORRIS, JH

HARMAN, M

HURSTHOUSE, MB

机构：

[1] UNIV STRATHCLYDE,DEPT PURE & APPL CHEM,295 CATHEDRAL ST,GLASGOW G1 1XL,SCOTLAND

[2] QUEEN MARY & WESTFIELD COLL,DEPT CHEM,LONDON E1 4NS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1992年 / 01期

关键词：

D O I：

10.1039/dt9920000119

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New sulfur-substituted derivatives of closo- and nido-monocarbon carboranes have been synthesised for their potential application in 10-B neutron capture therapy of tumours. The compounds 7-Me3N-4(6)-HS-nido-7-CB10H11 and 4,4'-, 6,6'- and 4,6'-S2(7-Me3N-nido-7-CB10H11)2 were obtained by Friedel-Crafts substitution of 7-Me3N-nido-7-CB10H12 with S2Cl2; high-temperature boron insertion and methylation of the products gave 1-Me2N-2-Me2S-closo-1-CB11H10 as a result of a cluster rearrangement process. Its structure has been confirmed by X-ray crystallography.

引用

页码：119 / 126

页数：8

共 31 条

[1] CRYSTAL AND MOLECULAR-STRUCTURE OF 10,10'-[B10H8(S(CH3)2)]2, 10,10'-BIS(DIMETHYL SULFIDE)HEXADECAHYDROICOSABORANE [J].