A NEW CARBAMAZEPINE METABOLITE IN UREMIC FILTRATE

被引：9

作者：

BEYER, C

SPITELLER, G

机构：

[1] Lehrstuhl Organische Chemie I, Universität Bayreuth, 8580, Bayreuth

来源：

XENOBIOTICA | 1992年 / 22卷 / 08期

关键词：

D O I：

10.3109/00498259209049908

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. After administration of carbamazepine (Tegretal(R)) to an epileptic patient suffering also from uraemia, a previously unknown metabolite was detected in the haemofiltrate. It was identified as the 10,11-dihydro-10-hydroxy-carbamazepine-O-beta-glucuronide. 2. Its identification was accomplished mainly by electron impact (EI), liquid secondary ion (LSI) mass spectrometry and n.m.r. spectroscopy.

引用

页码：1029 / 1035

页数：7

共 23 条

[1] 10,11-DIHYDRO-10,11-DIHYDROXY-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE, A METABOLITE OF CARBAMAZEPINE ISOLATED FROM HUMAN AND RAT URINE [J].