LIPIDS IN THE PROGRESSION OF CHRONIC-RENAL-FAILURE

被引：32

作者：

CAPPELLI, P ^{[1
]}

EVANGELISTA, M ^{[1
]}

BONOMINI, M ^{[1
]}

PALMIERI, PF ^{[1
]}

ALBERTAZZI, A ^{[1
]}

机构：

[1] UNIV CHIETI,INST NEPHROL,CHIETI,ITALY

来源：

NEPHRON | 1992年 / 62卷 / 01期

关键词：

APOLIPOPROTEINS; CHRONIC RENAL FAILURE; LIPIDS; URINARY PROTEIN EXCRETION;

D O I：

10.1159/000186991

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Lipid disturbances have been linked to the progression of chronic renal disease. We examined 52 patients with a creatinine clearance (CCr) of 38.5 +/- 7.9 ml/min due to various nephropathies, on free diet. Bimonthly, over a 12-month period, we assessed: serum creatinine (Cr); CCr; daily urinary urea excretion; urinary protein excretion per unit of residual renal function (UProt/CCr); total, HDL, VLDL and LDL cholesterol; triglycerides; Apo A, Apo B. Chronic renal failure was progressive in 22 patients with a slope of 1/Cr-0.00358 +/- 0.00247, stable in 30 with a slope of 0.00420 +/- 0.00285. Lipid parameters did not differ significantly between the two groups but for the lower Apo A and Apo A/Apo B ratio values in the progressive group. Overall slope inversely correlated with basal CCr; in the progressive patients the slope correlated with the percentage variation of UProt/CCr and only partially with the altered Apo profile.

引用

页码：31 / 35

页数：5

共 25 条

[1]

ALBERTAZZI A, 1989, CONTRIB NEPHROL, V75, P167

[2]

ANDERSON S, 1987, P67

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