UNUSUAL ORGANIZATION OF THE HUMAN T-CELL RECEPTOR BETA-CHAIN GENE-COMPLEX IS LINKED TO RECOMBINATION HOTSPOTS

被引：8

作者：

SEBOUN, E ^{[1
]}

HOUGHTON, L ^{[1
]}

HATEM, CJ ^{[1
]}

LINCOLN, R ^{[1
]}

HAUSER, SL ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT NEUROL,SAN FRANCISCO,CA 94143

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 11期

关键词：

INSERTION; DELETION-RELATED POLYMORPHISM; TCRB LOCUS;

D O I：

10.1073/pnas.90.11.5026

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two rare Sfi I polymorphisms of 360 kb and 280 kb present within the human T-cell antigen receptor beta-chain gene complex were revealed by pulsed-field gel electrophoresis. They represent allelic variants of the polymorphic 330- and 300-kb Sfi I fragments previously described. The 360-kb polymorphism results from duplication of the 30-kb DNA fragment responsible for the 330/300-kb insertion/ deletion-related polymorphism. The 280-kb polymorphism results from a 20-kb deletion from the 300-kb Sfi I allele. The rare polymorphisms also map on either side of a Sal I site located near a recombination hotspot, suggesting that germ-line duplications and deletions arose from nonhomologous crossover events.

引用

页码：5026 / 5029

页数：4

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