2 FATAL CASES OF HEPATITIS-B VIRUS CARRIERS AFTER CORTICOSTEROID-THERAPY FOR BRONCHIAL-ASTHMA

被引：16

作者：

KOGA, Y

KUMASHIRO, R

YASUMOTO, K

SHAKADO, S

ONO, N

NOGUCHI, H

NAGATA, K

SATA, M

ABE, H

KAKU, N

TANIKAWA, K

机构：

[1] From The Second Department of Medicine, Kurume University School of Medicine, Kurume

[2] Critical Care Center, Kurume University School of Medicine, Kurume

来源：

INTERNAL MEDICINE | 1992年 / 31卷 / 02期

关键词：

TYPE-B CHRONIC HEPATITIS; ACUTE LIVER FAILURE; FULMINANT HEPATITIS;

D O I：

10.2169/internalmedicine.31.208

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report two hepatitis B virus (HBV) carriers who had liver failure after withdrawal of corticosteroids (steroids) administered for treatment of serious asthmatic attacks. Liver functions deteriorated 1 to 2 wk after withdrawal of the steroid therapy and liver failure occurred. Steroid readministration and intensive therapy for liver failure did not prevent death. An excessive immune response provoked by steroid withdrawal and decreased reserve capacity due to underlying chronic liver disease were thought to be factors in the liver failure. Caution must be exercised in the administration of steroids to patients with underlying chronic HBV infection to prevent exacerbation of hepatitis. Prompt readministration of steroids is indicated if evidence of liver failure develops.

引用

页码：208 / 213

页数：6

共 11 条

[1]

Kumada H., Yoshiba A., Oyake E., Et al., Study of the seroconversion from e-Ag to e-Ab by corticosteroid treatment in the HBs positive chronic hepatitis, Acta Hepatol Jpn, 22, (1981)

[2]

Shimizu M., Adachi N., Tokita H., Et al., A case of chronic active hepatitis type B with severe liver dysfunction induced by steroid withdrawal therapy-Improved by remedication of corticosteroid, Acta Hepatol Jpn, 26, (1985)

[3]

Arase Y., Kumada H., Ikeda K., Et al., Three cases of chronic liver disease with severe liver dysfunction after corticosteroid withdrawal therapy, Acta Hepatol Jpn, 28, (1987)

[4]

Galbraith R.M., Eddleston A.L.W.F., Williams R., Et al., Fulminant hepatic failure in leukemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy, Lancet, 20, (1975)

[5]

Thung S.N., Gerber M.A., Klion F., Et al., Massive hepatic necrosis after chemotherapy withdrawal in a hepatitis B virus carrier, Arch Int Med, 145, (1985)

[6]

Tanaka H., Yasunaga M., Shirasawa H., Et al., Three cases of HBsAg carrier with fulminant liver failure induced by withdrawal of steroid therapy, Acta Hepatol Jpn, 29, (1988)

[7]

Akahane Y., Kiyosawa K., Nagata A., Et al., Studies on HBeAg/anti-HBe in HBsAg positive liver disease and asymptomatic HBsAg carriers (AsC) Part 2: Clinical significance of HBeAg/anti-HBe in HBsAg positive diseases, Acta Hepatol Jpn, 21, (1980)

[8]

Nishihara T., Yamada G., Mizuno M., Et al., Clinical studies on the cases of anti-HBe-positive chronic hepatitis with acute exacerbation, Acta Hepatol Jpn, 23, (1982)

[9]

Miura M., Nakamura M., Nakano Y., Et al., A case of anti-HBe positive chronic hepatitis type B with evolution of fulminant hepatitis-like fatal course due to HBV-reactivation, Acta Hepatol Jpn, 26, (1985)

[10]

Carman W.F., Jacyna M.R., Hadziyannis S., Et al., Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection, Lancet, 9, (1990)

← 1 2 →