FAMILIAL CLUSTERING OF MULTIPLE-SCLEROSIS IN A NORTHERN SWEDISH RURAL DISTRICT

被引：23

作者：

BINZER, M

FORSGREN, L

HOLMGREN, G

DRUGGE, U

FREDRIKSON, S

机构：

[1] UMEA UNIV, DEPT CLIN GENET, UMEA, SWEDEN

[2] UMEA UNIV, DEPT SOCIOL, UMEA, SWEDEN

[3] HUDDINGE HOSP, KAROLINSKA INST, DEPT NEUROL, S-14186 HUDDINGE, SWEDEN

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1994年 / 57卷 / 04期

关键词：

D O I：

10.1136/jnnp.57.4.497

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A small rural district in the most northerly province of Sweden was found to have a very high occurrence of multiple sclerosis. A total of 12 patients with multiple sclerosis among 4744 inhabitants were identified (five females, seven males), corresponding to a prevalence of 253/100 000. Many of the patients were related and a further 21 cases with multiple sclerosis (14 females, seven males), mostly living in the neighbouring area, have family ties to the district. A genealogical investigation showed that 22 of the 33 patients identified had ties of kinship and thus, to our knowledge, the largest aggregation of multiple sclerosis in a family is presented.

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页码：497 / 499

页数：3

相关论文

共 18 条

[1] MULTIPLE SCLEROSIS IN A SMALL NEW-ENGLAND COMMUNITY [J].

DEACON, WE ;

ALEXANDER, L ;

SIEDLER, HD ;

KURLAND, LT .

NEW ENGLAND JOURNAL OF MEDICINE, 1959, 261 (21) :1059-1061

[2] MULTIPLE-SCLEROSIS SIBLING PAIRS - CLUSTERED ONSET AND FAMILIAL PREDISPOSITION [J].

DOOLITTLE, TH ;

MYERS, RH ;

LEHRICH, JR ;

BIRNBAUM, G ;

SHEREMATA, W ;

FRANKLIN, GM ;

NELSON, LM ;

HAUSER, SL .

NEUROLOGY, 1990, 40 (10) :1546-1552

[3] FAMILIAL AMYLOIDOTIC POLYNEUROPATHY IN SWEDEN - A PEDIGREE ANALYSIS [J].

DRUGGE, U ;

ANDERSSON, R ;

CHIZARI, F ;

DANIELSSON, M ;

HOLMGREN, G ;

SANDGREN, O ;

SOUSA, A .

JOURNAL OF MEDICAL GENETICS, 1993, 30 (05) :388-392

[4] MULTIPLE-SCLEROSIS CLUSTERING IN A SMALL MASSACHUSETTS COMMUNITY, WITH POSSIBLE COMMON EXPOSURE 23 YEARS BEFORE ONSET [J].

EASTMAN, R ;

SHERIDAN, J ;

POSKANZER, DC .

NEW ENGLAND JOURNAL OF MEDICINE, 1973, 289 (15) :793-795

[5] A POPULATION-BASED STUDY OF MULTIPLE-SCLEROSIS IN TWINS [J].

EBERS, GC ;

BULMAN, DE ;

SADOVNICK, AD ;

PATY, DW ;

WARREN, S ;

HADER, W ;

MURRAY, TJ ;

SELAND, TP ;

DUQUETTE, P ;

GREY, T ;

NELSON, R ;

NICOLLE, M ;

BRUNET, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (26) :1638-1642

[6] A CLUSTER-FOCUS OF MULTIPLE-SCLEROSIS AT HENRIBOURG, SASKATCHEWAN [J].

HADER, WJ ;

IRVINE, DG ;

SCHIEFER, HB .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1990, 17 (04) :391-394

[7] MULTIPLE-SCLEROSIS IN A NATIONWIDE SERIES OF TWINS [J].

KINNUNEN, E ;

KOSKENVUO, M ;

KAPRIO, J ;

AHO, K .

NEUROLOGY, 1987, 37 (10) :1627-1629

[8] FAMILIAL INCIDENCE AND GEOGRAPHY IN MULTIPLE SCLEROSIS [J].

KURTZKE, JF .

ACTA NEUROLOGICA SCANDINAVICA, 1965, 41 (02) :127-&

[9] FURTHER NOTES ON DISABILITY EVALUATION IN MULTIPLE SCLEROSIS WITH SCALE MODIFICATIONS [J].

KURTZKE, JF .

NEUROLOGY, 1965, 15 (07) :654-+

[10]

KURTZKE JF, 1985, HDB CLIN NEUROLOGY, V47, P259