PIRACETAM-INDUCED CHANGES TO MEMBRANE PHYSICAL-PROPERTIES - A COMBINED APPROACH BY P-31 NUCLEAR-MAGNETIC-RESONANCE AND CONFORMATIONAL-ANALYSIS

被引:58
作者
PEUVOT, J
SCHANCK, A
DELEERS, M
BRASSEUR, R
机构
[1] FAC SCI AGRON ETAT GEMBLOUX,CTR BIOPHYS MOLEC NUMER,B-5030 GEMBLOUX,BELGIUM
[2] UNIV CATHOLIQUE LOUVAIN,CHIM PHYS & CRISTALLOG LAB,B-1348 LOUVAIN,BELGIUM
[3] UNIV CATHOLIQUE LOUVAIN,ADV MAT RES CTR,B-1348 LOUVAIN,BELGIUM
[4] UCB BIOPROD SA,PHARMACEUT SECTEUR,BRAINE LALLEUD,BELGIUM
[5] UCB BIOPROD SA,DEPT MED,B-1420 BRAINE LALLEUD,BELGIUM
关键词
PIRACETAM; MODEL MEMBRANE; P-31; NMR; CONFORMATIONAL ANALYSIS; ISOTROPIC STRUCTURE; PHYSICAL PROPERTIES;
D O I
10.1016/0006-2952(95)00225-O
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Piracetam, Nootropil(R) (2-oxo-1-pyrrolidine acetamide), is a drug promoting erythrocyte deformability. To establish the mode of action of this compound, we have investigated its influence on the organization of model phospholipid membranes. P-31 NMR data show that the drug induces a structural modification in liposomes made of phosphatidylcholine and phosphatidylethanolamine. Our conformational analysis results have allowed the interpretation of the effect of piracetam on these model membranes: the specific interaction between the drug molecules and the phosphate headgroups induces a new organization of the lipids favouring formation of mobile drug-phospholipid complexes that exhibit an isotropic-type signal in the P-31 NMR spectra.
引用
收藏
页码:1129 / 1134
页数:6
相关论文
共 20 条
[1]   MODE OF ORGANIZATION OF AMPHIPHILIC MOLECULES AT A LIPID WATER INTERFACE - A CONFORMATIONAL-ANALYSIS [J].
BRASSEUR, R ;
DELEERS, M ;
RUYSSCHAERT, JM .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1986, 114 (01) :277-281
[2]   THEORETICAL CONFORMATIONAL-ANALYSIS OF PHOSPHOLIPIDS BILAYERS [J].
BRASSEUR, R ;
GOORMAGHTIGH, E ;
RUYSSCHAERT, JM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 103 (01) :301-310
[3]   CONFORMATIONAL-ANALYSIS OF GRAMICIDIN-GRAMICIDIN INTERACTIONS AT THE AIR-WATER-INTERFACE SUGGESTS THAT GRAMICIDIN AGGREGATES INTO TUBE-LIKE STRUCTURES SIMILAR AS FOUND IN THE GRAMICIDIN-INDUCED HEXAGONAL H-II PHASE [J].
BRASSEUR, R ;
KILLIAN, JA ;
DEKRUIJFF, B ;
RUYSSCHAERT, JM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 903 (01) :11-17
[4]  
BRASSEUR R, 1990, MOL DESCRIPTION BIOL, V1
[5]   P-31 NMR-STUDIES OF UNSONICATED AQUEOUS DISPERSIONS OF NEUTRAL AND ACIDIC PHOSPHOLIPIDS - EFFECTS OF PHASE-TRANSITIONS, P2H AND DIVALENT-CATIONS ON MOTION IN PHOSPHATE REGION OF POLAR HEADGROUP [J].
CULLIS, PR ;
DEKRUYFF, B .
BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 436 (03) :523-540
[6]   POLYMORPHIC PHASE BEHAVIOR OF LIPID MIXTURES AS DETECTED BY P-31 NMR - EVIDENCE THAT CHOLESTEROL MAY DESTABILIZE BILAYER STRUCTURE IN MEMBRANE SYSTEMS CONTAINING PHOSPHATIDYLETHANOLAMINE [J].
CULLIS, PR ;
DEKRUIJFF, B .
BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 507 (02) :207-218
[7]   POLYMORPHIC PHASE BEHAVIOR OF CARDIOLIPIN AS DETECTED BY P-31 NMR AND FREEZE-FRACTURE TECHNIQUES - EFFECTS OF CALCIUM, DIBUCAINE AND CHLORPROMAZINE [J].
CULLIS, PR ;
VERKLEIJ, AJ ;
VERVERGAERT, PHJT .
BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 513 (01) :11-20
[8]  
CULLIS PR, 1973, FEBS LETT, V70, P223
[9]   FURTHER ASPECTS OF THE CA2+-DEPENDENT POLYMORPHISM OF BOVINE HEART CARDIOLIPIN [J].
DEKRUIJFF, B ;
VERKLEIJ, AJ ;
LEUNISSENBIJVELT, J ;
VANECHTELD, CJA ;
HILLE, J ;
RIJNBOUT, H .
BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 693 (01) :1-12
[10]   OCCURRENCE OF LIPIDIC PARTICLES IN LIPID BILAYERS AS SEEN BY P-31-NMR AND FREEZE-FRACTURE ELECTRON-MICROSCOPY [J].
DEKRUIJFF, B ;
VERKLEY, AJ ;
VANECHTELD, CJA ;
GERRITSEN, WJ ;
MOMBERS, C ;
NOORDAM, PC ;
DEGIER, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 555 (02) :200-209