PIRACETAM-INDUCED CHANGES TO MEMBRANE PHYSICAL-PROPERTIES - A COMBINED APPROACH BY P-31 NUCLEAR-MAGNETIC-RESONANCE AND CONFORMATIONAL-ANALYSIS

被引：58

作者：

PEUVOT, J

SCHANCK, A

DELEERS, M

BRASSEUR, R

机构：

[1] FAC SCI AGRON ETAT GEMBLOUX,CTR BIOPHYS MOLEC NUMER,B-5030 GEMBLOUX,BELGIUM

[2] UNIV CATHOLIQUE LOUVAIN,CHIM PHYS & CRISTALLOG LAB,B-1348 LOUVAIN,BELGIUM

[3] UNIV CATHOLIQUE LOUVAIN,ADV MAT RES CTR,B-1348 LOUVAIN,BELGIUM

[4] UCB BIOPROD SA,PHARMACEUT SECTEUR,BRAINE LALLEUD,BELGIUM

[5] UCB BIOPROD SA,DEPT MED,B-1420 BRAINE LALLEUD,BELGIUM

来源：

BIOCHEMICAL PHARMACOLOGY | 1995年 / 50卷 / 08期

关键词：

PIRACETAM; MODEL MEMBRANE; P-31; NMR; CONFORMATIONAL ANALYSIS; ISOTROPIC STRUCTURE; PHYSICAL PROPERTIES;

D O I：

10.1016/0006-2952(95)00225-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Piracetam, Nootropil(R) (2-oxo-1-pyrrolidine acetamide), is a drug promoting erythrocyte deformability. To establish the mode of action of this compound, we have investigated its influence on the organization of model phospholipid membranes. P-31 NMR data show that the drug induces a structural modification in liposomes made of phosphatidylcholine and phosphatidylethanolamine. Our conformational analysis results have allowed the interpretation of the effect of piracetam on these model membranes: the specific interaction between the drug molecules and the phosphate headgroups induces a new organization of the lipids favouring formation of mobile drug-phospholipid complexes that exhibit an isotropic-type signal in the P-31 NMR spectra.

引用

页码：1129 / 1134

页数：6

共 20 条

[1] MODE OF ORGANIZATION OF AMPHIPHILIC MOLECULES AT A LIPID WATER INTERFACE - A CONFORMATIONAL-ANALYSIS [J].