EFFECT OF NEONATAL HANDLING ON LEARNED HELPLESSNESS MODEL OF DEPRESSION

被引：41

作者：

COSTELA, C ^{[1
]}

TEJEDORREAL, P ^{[1
]}

MICO, JA ^{[1
]}

GIBERTRAHOLA, J ^{[1
]}

机构：

[1] SCH MED CADIZ, DEPT NEUROSCI, PSYCHOPHARMACOL LAB, E-11003 CADIZ, SPAIN

来源：

PHYSIOLOGY & BEHAVIOR | 1995年 / 57卷 / 02期

关键词：

HANDLING; LEARNED HELPLESSNESS; RAT; EMOTIVITY; DEPRESSION;

D O I：

10.1016/0031-9384(94)E0113-I

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The present study was undertaken to investigate the effects of neonatal handling on learned helplessness (LH) model of depression in the rat. We also investigated the effect of neonatal handling on behavior in an open field test of emotionality. The handling procedure reduced helplessness behavior, with a decrease in the number of escape failures, an increase in the number of avoidance responses, and a decrease in the escape latency in the shuttle-box after induction of LH. In addition, handling during infancy decreased the number of boli in an open field test, which suggests that the level of emotivity in adulthood was reduced. It is suggested that handling in infancy improves behavioral adaptation to the environment, including enhanced adaptive response to stress.

引用

页码：407 / 410

页数：4

共 17 条

[1]

BROADHURST PL, 1960, EXPT PERSONALITY, V1, P2

[2] CORPUS-CALLOSUM - INTERACTIVE EFFECTS OF INFANTILE HANDLING AND TESTOSTERONE IN THE RAT [J].

DENENBERG, VH ;

FITCH, RH ;

SCHROTT, LM ;

COWELL, PE ;

WATERS, NS .

BEHAVIORAL NEUROSCIENCE, 1991, 105 (04) :562-566

[3] INCREASED ADRENOCORTICAL ACTIVITY IN NEONATAL RAT FOLLOWING HANDLING [J].

DENENBERG, VH ;

BRUMAGHIM, JT ;

HALTMEYER, GC ;

ZARROW, MX .

ENDOCRINOLOGY, 1967, 81 (05) :1047-+

[4] INFANTILE (HANDLING) STIMULATION AND BEHAVIOR IN YOUNG ROMAN HIGH-AVOIDANCE AND LOW-AVOIDANCE RATS [J].

FERNANDEZTERUEL, A ;

ESCORIHUELA, RM ;

DRISCOLL, P ;

TOBENA, A ;

BATTIG, K .

PHYSIOLOGY & BEHAVIOR, 1991, 50 (03) :563-565

[5] EFFECTS OF EARLY POSTNATAL HANDLING ON BRAIN BETA-ADRENOCEPTORS AND BEHAVIOR IN TESTS RELATED TO STRESS [J].

HILAKIVICLARKE, LA ;

TURKKA, J ;

LISTER, RG ;

LINNOILA, M .

BRAIN RESEARCH, 1991, 542 (02) :286-292

[6] THE BETA-ENDORPHIN RESPONSE TO STRESS DURING POSTNATAL-DEVELOPMENT IN THE RAT [J].

INY, LJ ;

GIANOULAKIS, C ;

PALMOUR, RM ;

MEANEY, MJ .

DEVELOPMENTAL BRAIN RESEARCH, 1987, 31 (02) :177-181

[7] HORMONAL INFLUENCES ON BRAIN ORGANIZATION IN INFANT RATS [J].

LEVINE, S ;

MULLINS, RF .

SCIENCE, 1966, 152 (3729) :1585-+

[8] SHUTTLE-BOX DEFICITS INDUCED BY INESCAPABLE SHOCKS IN RATS - REVERSAL BY THE BETA-ADRENOCEPTOR STIMULANTS CLENBUTEROL AND SALBUTAMOL [J].

MARTIN, P ;

SOUBRIE, P ;

SIMON, P .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 24 (02) :177-181

[9] EFFECT OF NEONATAL HANDLING ON AGE-RELATED IMPAIRMENTS ASSOCIATED WITH THE HIPPOCAMPUS [J].

MEANEY, MJ ;

AITKEN, DH ;

VANBERKEL, C ;

BHATNAGAR, S ;

SAPOLSKY, RM .

SCIENCE, 1988, 239 (4841) :766-768

[10] CELLULAR MECHANISMS UNDERLYING THE DEVELOPMENT AND EXPRESSION OF INDIVIDUAL-DIFFERENCES IN THE HYPOTHALAMIC PITUITARY-ADRENAL STRESS RESPONSE [J].

MEANEY, MJ ;

VIAU, V ;

BHATNAGAR, S ;

BETITO, K ;

INY, LJ ;

ODONNELL, D ;

MITCHELL, JB .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1991, 39 (02) :265-274

← 1 2 →