LONG-TERM TREATMENT WITH THE COMBINATION ETHINYLESTRADIOL AND CYPROTERONE-ACETATE IN POLYCYSTIC-OVARY-SYNDROME

被引:40
作者
FALSETTI, L
GALBIGNANI, E
机构
[1] Department of Obstetrics, Gynecology - University of Brescia
关键词
D O I
10.1016/0010-7824(90)90002-D
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
This study evaluates the effect of therapy over a long period of time (36 cycles without interruption) with the monophasic combination containing 0.035 mg of ethinylestradiol and 2 mg of cyproterone acetate (EE35-CPA) on hormonal and clinical parameters of 66 patients with polycystic ovary syndrome (PCOS). During the administration of the pill a significant decrease in the LH/FSH ratio and in adrenal and ovarian androgens has been observed, as well as a significant increase of the Sex Hormone Binding Globulin (SHBG). The progressive decrease of the total androgenic activity explains the clinical results that have been obtained: at the 36th cycle of therapy acne disappeared in 100% of the cases, seborrea in 76.4% and hirsutism in 75%. Our results underline the need for a continuous administration without interruption of the pill with CPA in patients with clinical hyperandrogenic symptoms. © 1990.
引用
收藏
页码:611 / 619
页数:9
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