PHOSPHOLIPID IN THE HEXAGONAL-II PHASE IS IMMUNOGENIC - EVIDENCE FOR IMMUNORECOGNITION OF NONBILAYER LIPID PHASES INVIVO

被引：110

作者：

RAUCH, J ^{[1
]}

JANOFF, AS ^{[1
]}

机构：

[1] LIPOSOME CO INC,PRINCETON,NJ 08540

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 11期

关键词：

autoantibodies; autoimmunity; nonbilayer lipid; systemic lupus erythematosus;

D O I：

10.1073/pnas.87.11.4112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunization of mice with phosphatidylethanolamine in the hexagonal II phase but not the bilayer phase resulted in the induction of anti-phospholipid antibodies. These antibodies, which were strongly reactive with phosphatidylethanolamine and crossreactive with cardiolipin, had functional lupus anticoagulant activity and were characteristic of autoantibodies common in patients with autoimmune disease. Recognition of the hexagonal II phase by the afferent limb of the immune system suggests that nonbilayer phospholipids can arise in the course of membrane remodeling and induce the autoantibodies of disease.

引用

页码：4112 / 4114

页数：3

共 38 条

[1]

ALVING BM, 1987, CLIN EXP IMMUNOL, V69, P403

[2] ANTIBODIES TO LIPOSOMES, PHOSPHOLIPIDS AND PHOSPHATE-ESTERS [J].