STEROLS OF KALANCHOE-PINNATA - 1ST REPORT OF THE ISOLATION OF BOTH C-24 EPIMERS OF 24-ALKYL-DELTA-25-STEROLS FROM A HIGHER-PLANT

被引：31

作者：

AKIHISA, T ^{[1
]}

KOKKE, WCMC ^{[1
]}

TAMURA, T ^{[1
]}

MATSUMOTO, T ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT SYNTHET CHEM,KING OF PRUSSIA,PA 19406

来源：

LIPIDS | 1991年 / 26卷 / 08期

关键词：

D O I：

10.1007/BF02536432

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eighteen sterols were isolated from the aerial parts of Kalanchoe pinnata (Crassulaceae) including four novel sterols, viz. (24R)-stigmasta-5,25-dien-3-beta-ol (24-epiclerosterol), (24R)-5-alpha-stigmasta-7,25-dien-3-beta-ol, 5-alpha-stigmast-24-en-3-beta-ol, and 25-methyl-5-alpha-ergost-24(28)-en-3-beta-ol. 24-Epiclerosterol and its DELTA-7-analog occur together with their 24S/beta-epimers in the same plant making this the first report of the isolation of both C-24 epimers of DELTA-25-unsaturated 24-alkylsterols from a non-marine organism. Iodine-catalyzed isomerization of stigmasta-5,24-dien-3-beta-ol (24-ethyldesmosterol), the main sterol of K. pinnata, yielded 24-epiclerosterol among other products.

引用

页码：660 / 665

页数：6

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