IS THE GENOTOXIC EFFECT OF ARSENIC MEDIATED BY OXYGEN FREE-RADICALS

被引：132

作者：

NORDENSON, I

BECKMAN, L

机构：

[1] UMEA UNIV,DEPT MED GENET,S-90185 UMEA,SWEDEN

[2] UMEA UNIV,CLIN GENET LAB,S-90185 UMEA,SWEDEN

来源：

HUMAN HEREDITY | 1991年 / 41卷 / 01期

关键词：

ARSENIC; CATALASE; SISTER CHROMATID EXCHANGES; SUPEROXIDE DISMUTASE; OXYGEN FREE RADICALS;

D O I：

10.1159/000153979

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Previous investigations have shown that trivalent arsenic is inducing chromosomal aberrations and sister chromatid exchanges (SCEs). In a search for the genotoxic mechanism we have studied the effects of the oxygen-radical-scavenging enzymes superoxide dismutase (SOD) and catalase (CAT) on arsenic-induced SCEs in cultured human lymphocytes. The results indicate that SOD and possibly also CAT have a protective effect against arsenic-induced DNA damage. Arsenic, which is emitted in environmental pollutions e.g. from smelters and coal-fired power plants, appears to be underestimated as environmental mutagen and potential synergist to ionizing radiation.

引用

页码：71 / 73

页数：3

共 11 条

[1] INTERACTION BETWEEN SOME COMMON GENOTOXIC AGENTS [J].