RPS4 MAPS NEAR THE INACTIVATION CENTER ON THE MOUSE X-CHROMOSOME

被引:16
作者
HAMVAS, RMJ
ZINN, A
KEER, JT
FISHER, EMC
BEERROMERO, P
BROWN, SDM
PAGE, DC
机构
[1] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND
[2] MIT,WHITEHEAD INST,HOWARD HUGHES RES LABS,CAMBRIDGE,MA 02142
[3] MIT,DEPT BIOL,CAMBRIDGE,MA 02142
基金
英国医学研究理事会; 美国国家卫生研究院;
关键词
D O I
10.1016/0888-7543(92)90386-7
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
RPS4Y, a Y-linked gene in humans, appears to encode an isoform of ribosomal protein S4. A homologous locus on the human X chromosome, RPS4X, lies close to the X-inactivation center but fails to undergo X-inactivation. We have isolated a genomic clone from the mouse Rps4 locus, the homolog of human RPS4X. We derived an intron probe that hybridizes to the functional Rps4 locus but does not cross-hybridize to related sequences elsewhere in the mouse genome. Genetic mapping utilizing interspecific mouse backcrosses and the intronspecific probe demonstrates that Rps4 maps close to the Phka locus on the mouse X chromosome and in the vicinity of the X-inactivation center. The gene order Ccg-1-Rps4 Phka-Xist-Pgk-1 is conserved between mouse and human. © 1992.
引用
收藏
页码:363 / 367
页数:5
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