5-HETEROARYL-2-THIOPHENECARBOXYLIC ACIDS - OXAZOLES AND OXADIAZOLES

被引：20

作者：

GODDARD, CJ

机构：

[1] Department of Medicinal Chemistry, Pfizer Central Research, Groton, Connecticut

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 01期

关键词：

D O I：

10.1002/jhet.5570280104

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel thiophene-2-carboxylic acids bearing alkyl and aryl-substituted oxazole and oxadiazole rings is reported. Sequential functionalization of the key precursor, 5-formyl-2-thiophenecarboxylic acid furnished the intermediate carboxylic acid esters which were converted into desired acids by basic cleavage.

引用

页码：17 / 28

页数：12

共 32 条

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