SPECIFIC SUPPRESSION OF ALLOGRAFT-REJECTION BY SOLUBLE CLASS-I ANTIGEN AND COMPLEXES WITH MONOCLONAL-ANTIBODY

被引：124

作者：

SUMIMOTO, R ^{[1
]}

KAMADA, N ^{[1
]}

机构：

[1] NATL CHILDRENS MED RES CTR,DEPT EXPTL SURG,3-35-31 TAISHIDO,SETAGAYA KU,TOKYO,JAPAN

来源：

TRANSPLANTATION | 1990年 / 50卷 / 04期

关键词：

D O I：

10.1097/00007890-199010000-00029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this experiment, we investigated the effect of daily injection or continuous slow infusion of either DA (MHC haplotype, RTla) serum or soluble DA class 1 MHC antigen or its complexes with monoclonal antibody on rejection of heterotopic heart allograft in the combination of PVG.RTla (RTla) donor into PVG (RT1c) recipient. DA serum delayed significantly both the early and late rejection of PVG.RTla heart grafts in PVG recipients. Removal of soluble class I MHC antigen from DA serum by affinity chromatography on a monoclonal anti-class I antibody column completely abolished the immunosuppressive effect. Continuous infusion of purified soluble class I antigen from DA rat liver, even from day 4 after heart grafting, induced a significant prolongation of graft survival. This effectiveness was donor- specific and amplified by the mixture of monoclonal anti-class l(RTla) antibody with DA serum-this being induced only by using continuous infusion but not by daily injection. The results indicate that soluble class I antigen can act as a specific immunosuppressive agent in allograft rejection and that its effect is amplified by monoclonal anti-class 1 antibody. © 1990 by Williams & Wilkins.

引用

页码：678 / 682

页数：5

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