EXPRESSION OF EPIDERMAL GROWTH-FACTOR IN THE RAT-KIDNEY - AN IMMUNOCYTOCHEMICAL AND INSITU HYBRIDIZATION STUDY

被引：70

作者：

SALIDO, EC

LAKSHMANAN, J

FISHER, DA

SHAPIRO, LJ

BARAJAS, L

机构：

[1] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT PEDIAT,TORRANCE,CA 90509

[2] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,SCH MED,DEPT BIOL CHEM,TORRANCE,CA 90509

[3] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,HOWARD HUGHES MED INST,TORRANCE,CA 90509

来源：

HISTOCHEMISTRY | 1991年 / 96卷 / 01期

关键词：

D O I：

10.1007/BF00266763

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The renal localization and the site of synthesis of epidermal growth factor (EGF) were investigated in the rat kidney by immunohistochemistry and in situ hybridization techniques. EGF was localized in the cells of the thick ascending limb of Henle (TAL) and distal convoluted tubule (DCT). At the ultrastructural level, EGF immunoreactivity was distributed on the apical membrane and trans-Golgi complex of the TAL and DCT cells. These segments of the rat nephron also hybridized to prepro-EGF cRNA probes in a specific manner, indicating that TAL and DCT are the sites of EGF synthesis in the rat kidney.

引用

页码：65 / 72

页数：8

共 39 条

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