IDENTIFICATION OF A SPLEEN CELL-DERIVED FACTOR THAT INHIBITS SENSITIZATION OF MURINE PERITONEAL MAST-CELLS AS INTERFERON-GAMMA

被引：7

作者：

COLEMAN, JW

MORRIS, AG

机构：

[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL L69 3BX,ENGLAND

[2] UNIV WARWICK,DEPT BIOL SCI,CLIN RES CTR,INTERFERON & CELLULAR IMMUN RES GRP,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 94卷 / 1-4期

关键词：

D O I：

10.1159/000235356

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We present evidence that a spleen cell-derived factor that inhibits the sensitization of mouse peritoneal mast cells is IFN-gamma. Conditioned medium (CM) from Con A-activated mouse spleen cells and recombinant MuIFN-gamma both inhibited antigen-induced 5-HT release from peritoneal mast cells when added at the sensitization stage, but were without effect on presensitized cells. Both preparations were active at dilutions corresponding to similar levels of IFN activity (1-10 units/ml). The inhibitory activity of CM was blocked by a rat monoclonal MuIFN-gamma-neutralizing antibody, thus confirming that IFN-gamma was the active molecule.

引用

页码：179 / 180

页数：2