CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - EFFECT OF AGE AT THE TIME OF SENSITIZATION ON CLINICAL COURSE AND PATHOLOGY

被引:31
作者
LASSMANN, H
WISNIEWSKI, HM
机构
[1] New York State Institute for Basic Research in Mental Retardation, Staten Island, 10314, NY
关键词
Demyelinating diseases; Multiple sclerosis; Relapsing EAE;
D O I
10.1007/BF00717033
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Experimental allergic encephalomyelitis was induced by sensitization with guinea pig spinal cord in complete Freund's adjuvant with increased content of myobacterium in Hartley guinea pigs between the first and 28th day after birth. The animals either died during acute EAE or showed chronic progressive, chronic relapsing or chronic EAE with delayed onset. In animals immunized between the 1 and 13 day after birth, predominatly ordinary and chronic progressive EAE was noted, whereas animals sensitized between the 14th and 23rd day frequently suffered from hyperacute or chronic relapsing EAE. Immunization on the 24th day led to very high mortality in acute EAE. The relation of the pathohistologic alterations to different types of human inflammatory demyelinative disease is discussed. © 1979 Springer-Verlag.
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页码:111 / 116
页数:6
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