A MACROLIDE 3-O-ACYLTRANSFERASE GENE FROM THE MIDECAMYCIN-PRODUCING SPECIES STREPTOMYCES-MYCAROFACIENS

被引：50

作者：

HARA, O

HUTCHINSON, CR

机构：

[1] UNIV WISCONSIN,SCH PHARM,MADISON,WI 53706

[2] MEIJI SEIKA KAISHA LTD,PHARMACEUT RES CTR,KOHOKU KU,YOKOHAMA,KANAGAWA 222,JAPAN

[3] UNIV WISCONSIN,DEPT BACTERIOL,MADISON,WI 53706

来源：

JOURNAL OF BACTERIOLOGY | 1992年 / 174卷 / 15期

关键词：

D O I：

10.1128/JB.174.15.5141-5144.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene.

引用

页码：5141 / 5144

页数：4

共 21 条

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