SYNTHESIS OF HEXADECYLPHOSPHO[METHYL-C-14]-CHOLINE

被引：20

作者：

GEILEN, CC ^{[1
]}

SAMSON, A ^{[1
]}

WIEDER, T ^{[1
]}

WILD, H ^{[1
]}

REUTTER, W ^{[1
]}

机构：

[1] BAYER AG,CHEM SCI LABS PHARMA,W-5600 WUPPERTAL 1,GERMANY

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 12期

关键词：

HEXADECYLPHOSPHO[METHYL-C-14]-CHOLINE; PHOSPHOLIPID ANALOGS; ETHERLIPIDS;

D O I：

10.1002/jlcr.2580311216

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Hexadecylphospho[methyl-C-14]-choline was synthesized in two steps from the tetra-n-butyl-ammonium salt of phosphoryl[methyl-C-14]-choline and 1-bromohexadecane, and purified by column chromatography on Silica gel. The total yield of the radioactive synthesis was 35%, whereas the total yield of the non-radioactive synthesis was 40%. Hexadecylphospho[methyl-C-14]-choline may serve as a useful tool for pharmacokinetic and biochemical studies of this new antitumor drug.

引用

页码：1071 / 1076

页数：6

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