POPOLOHUANONE-E, A TOPOISOMERASE-II INHIBITOR WITH SELECTIVE LUNG-TUMOR CYTOTOXICITY FROM THE POHNPEI SPONGE DYSIDEA SP

被引：53

作者：

CARNEY, JR ^{[1
]}

SCHEUER, PJ ^{[1
]}

机构：

[1] UNIV HAWAII, DEPT CHEM, HONOLULU, HI 96822 USA

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(00)79211-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An oxidatively-dimerized arenarol derivative, popolohuanone E (1), was isolated from a Pohnpei sponge. The compound is a potent inhibitor of topoisomerase-II and shows selective cytotoxicity against the A549 non-small cell human lung cancer cell line.

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页码：3727 / 3730

页数：4

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