STAGE SPECIFIC, (O4+GALC-) ISOLATED OLIGODENDROCYTE PROGENITORS PRODUCE MBP+MYELIN INVIVO

被引:28
作者
WARRINGTON, AE [1 ]
BARBARESE, E [1 ]
PFEIFFER, SE [1 ]
机构
[1] UNIV CONNECTICUT, SCH MED, DEPT NEUROL, FARMINGTON, CT 06032 USA
关键词
MYELINOGENESIS; OLIGODENDROCYTE; PROGENITOR; SHIVERER; TRANSPLANTATION;
D O I
10.1159/000111652
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
O4+/A007+GalC- proligodendroblasts represent a distinct stage of development in the oligodendrocyte lineage, occurring just prior to the appearance of postmitotic GalC+ oligodendrocytes. These cells, isolated directly from postnatal rat telencephalon by an immunopanning procedure, can terminally differentiate and myelinate axons when transplanted back into an in vivo environment. Specifically, after 30 days in the brain of newborn shiverer mouse hosts, O4+GalC- oligodendrocyte progenitors produced myelin basic protein positive (MBP+) patches. These MBP+ patches, examined by both light and confocal microscopy, contained oligodendrocyte cell bodies and ensheathed host shiverer axons morphologically similar to those found in normal rat brain at an analogous age. These results suggest that isolated O4+GalC- cells can become biochemically mature oligodendrocytes with the capacity to elaborate myelin sheaths, and further define the period of development during which oligodendrocytes retain their capacity to myelinate axons when given a receptive environment.
引用
收藏
页码:93 / 97
页数:5
相关论文
共 27 条
[1]  
BANSAL R, IN PRESSS J NEUROCHE
[2]   THE RELATIONSHIP BETWEEN TYPE-1 ASTROCYTES, SCHWANN-CELLS AND OLIGODENDROCYTES FOLLOWING TRANSPLANTATION OF GLIAL-CELL CULTURES INTO DEMYELINATING LESIONS IN THE ADULT-RAT SPINAL-CORD [J].
BLAKEMORE, WF ;
CRANG, AJ .
JOURNAL OF NEUROCYTOLOGY, 1989, 18 (04) :519-528
[3]   DEVELOPMENT OF MACROGLIAL CELLS IN RAT CEREBELLUM .1. USE OF ANTIBODIES TO FOLLOW EARLY INVIVO DEVELOPMENT AND MIGRATION OF OLIGODENDROCYTES [J].
CURTIS, R ;
COHEN, J ;
FOKSEANG, J ;
HANLEY, MR ;
GREGSON, NA ;
REYNOLDS, R ;
WILKIN, GP .
JOURNAL OF NEUROCYTOLOGY, 1988, 17 (01) :43-54
[4]  
DUBOISDALCQ M, 1987, EMBO J, V177, P105
[5]   TRANSPLANTED TYPE-1 ASTROCYTES FACILITATE REPAIR OF DEMYELINATING LESIONS BY HOST OLIGODENDROCYTES IN ADULT-RAT SPINAL-CORD [J].
FRANKLIN, RJM ;
CRANG, AJ ;
BLAKEMORE, WF .
JOURNAL OF NEUROCYTOLOGY, 1991, 20 (05) :420-430
[6]   MONOCLONAL-ANTIBODY A2B5 REACTS WITH MANY GANGLIOSIDES IN NEURONAL TISSUE [J].
FREDMAN, P ;
MAGNANI, JL ;
NIRENBERG, M ;
GINSBURG, V .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1984, 233 (02) :661-666
[7]   MYELINATION BY TRANSPLANTED FETAL AND NEONATAL OLIGODENDROCYTES IN A DYSMYELINATING MUTANT [J].
FRIEDMAN, E ;
NILAVER, G ;
CARMEL, P ;
PERLOW, M ;
SPATZ, L ;
LATOV, N .
BRAIN RESEARCH, 1986, 378 (01) :142-146
[8]   TRANSPLANTATIONS OF NEWBORN CNS FRAGMENTS INTO THE BRAIN OF SHIVERER MUTANT MICE - EXTENSIVE MYELINATION BY TRANSPLANTED OLIGODENDROCYTES .2. ELECTRON-MICROSCOPIC STUDY [J].
GANSMULLER, A ;
LACHAPELLE, F ;
BARONVANEVERCOOREN, A ;
HAUW, JJ ;
BAUMANN, N ;
GUMPEL, M .
DEVELOPMENTAL NEUROSCIENCE, 1986, 8 (04) :197-207
[9]  
GARD AL, 1989, DEVELOPMENT, V106, P119
[10]   SURVIVAL AND DIFFERENTIATION OF OLIGODENDROCYTES FROM NEURAL TISSUE TRANSPLANTED INTO NEWBORN MOUSE-BRAIN [J].
GUMPEL, M ;
BAUMANN, N ;
RAOUL, M ;
JACQUE, C .
NEUROSCIENCE LETTERS, 1983, 37 (03) :307-311