HETEROACID PHOSPHATIDYLCHOLINES WITH DIFFERENT AMOUNTS OF UNSATURATION RESPOND DIFFERENTLY TO CHOLESTEROL

被引：34

作者：

HERNANDEZBORRELL, J

KEOUGH, KMW

机构：

[1] MEM UNIV NEWFOUNDLAND,DEPT BIOCHEM,ST JOHNS A1B 3X9,NF,CANADA

[2] MEM UNIV NEWFOUNDLAND,DISCIPLINE PEDIAT,ST JOHNS A1B 3X9,NF,CANADA

[3] UNIV BARCELONA,DEPT FARM,UNITAT FISICOQUIM,E-08028 BARCELONA,SPAIN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1153卷 / 02期

基金：

英国医学研究理事会;

关键词：

CHOLESTEROL; PHOSPHATIDYLCHOLINE; PHASE TRANSITION; DSC; UNSATURATION; LIPID CHOLESTEROL INTERACTION;

D O I：

10.1016/0005-2736(93)90416-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effectiveness of cholesterol in removing the gel to liquid crystal phase transition of dispersions of pure molecular species of phosphatidylcholines (PC) that is detectable by differential scanning calorimetry (DSC) has been explored. The effect of cholesterol on 16:0-18:0 PC, 16:0-18:1 PC, 16:0-18:2 PC, 16:0-20:4 PC and 16:0-22:6 PC has been determined. Cholesterol caused a concentration-dependent removal of the detectable phase transitions in all cases. It required very little cholesterol to remove the phase transition 16:0-18:2 PC (< 17 mol% of cholesterol in PC). It required greater than or equal to 35 mol% cholesterol to remove Delta H for 16:0-18:0 PC and 16:0-22:6 PC. About 20-25 mol% cholesterol caused disappearance of the transitional endotherm of 16:0-18:1 PC and 16:0-20:4 PC. The findings indicate that the magnitude of the influence of cholesterol on phospholipid is dependent on the degree of unsaturation in the lipid.

引用

页码：277 / 282

页数：6

共 30 条

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