LIQUID-CHROMATOGRAPHIC ANALYSIS AND STABILITY OF BENZO[A]PYRENE-TETROLS IN BLOOD PROTEIN ADDUCTS IN RATS AFTER EXPOSURE TO BENZO[A]PYRENE

被引：11

作者：

JANSEN, EHJM ^{[1
]}

VANDENBERG, RH ^{[1
]}

KROESE, ED ^{[1
]}

机构：

[1] NATL INST PUBL HLTH & ENVIRONM PROTECT,CARCINOGENESIS & MUTAGENESIS LAB,3720 BA BILTHOVEN,NETHERLANDS

来源：

ANALYTICA CHIMICA ACTA | 1994年 / 290卷 / 1-2期

关键词：

LIQUID CHROMATOGRAPHY; BENZO[A]PYRENE-TETROLS; BLOOD PROTEIN ADDUCTS; HEMOGLOBIN;

D O I：

10.1016/0003-2670(94)80043-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The stability of the four benzo[a]pyrene-7,8,9,10-tetrahydrotetrols is investigated under hydrolysis conditions necessary to release the tetrols from haemoglobin. Two benzo[a]pyrene (BP)-tetrols appeared to be rather stable under hydrolysis conditions, whereas two other BP-tetrols were unstable and were transformed (partially) into the former two tetrols. In addition a method of analysis of BP-tetrols hydrolysed from rat haemoglobin adducts of rats exposed to BP is indicated and discussed.

引用

页码：86 / 93

页数：8

共 7 条

[1] BENZO[A]PYRENE GLOBIN ADDUCTS DETECTED BY SYNCHRONOUS FLUORESCENCE SPECTROPHOTOMETRY - METHOD DEVELOPMENT AND RELATION TO LUNG DNA ADDUCTS IN MICE [J].