DEVELOPMENT OF POLY (DIALKYL METHYLIDENEMALONATE) NANOPARTICLES AS DRUG CARRIERS

被引：10

作者：

MBELA, TKM

POUPAERT, JH

DUMONT, P

HAEMERS, A

机构：

[1] UNIV INSTELLING ANTWERP, DEPT PHARMACEUT CHEM, UNIV PLEIN 1, B-2610 Antwerp, BELGIUM

[2] UNIV KINSHASA, FAC PHARM, DEPT PHARMACEUT & DRUG ANAL, KINSHASA 11, DEM REP CONGO

[3] UNIV CATHOLIQUE LOUVAIN, FAC MED, DEPT PHARMACEUT SCI, MED CHEM LAB, B-1200 BRUSSELS, BELGIUM

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 92卷 / 1-3期

关键词：

DIALKYLMETHYLIDENEMALONATE; POLYMETHYLIDENEMALONATE ESTER; POLY(DIALLYLMETHYLIDENE MALONATE); POLY(CYCLOHEXYLETHYLMETHYLIDENE MALONATE); NANOPARTICLES; PRIMAQUINE;

D O I：

10.1016/0378-5173(93)90265-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two novel dialkylmethylidenemalonate (DAMM) analogs: diallylmethylidenemalonate (AAMM, 1b) and cyclohexylethylmethylidenemalonate (CEMM, 1c) were synthesized and evaluated for their capacity to polymerise to stable nanoparticles and to adsorb primaquine diphosphate (PQ). PQ loading onto poly-AAMM (PAAMM, 1b) and poly-CEMM (PCEMM, 1c) was up to 90% in the pH range from 6.0 to 8.5. A significant improvement of the physicochemical characteristics and the PQ desorption capacity of the nanoparticles was achieved in this series of PDAMM analogs.

引用

页码：71 / 79

页数：9

共 30 条

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